Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system
ML Cuzner, G Opdenakker - Journal of neuroimmunology, 1999 - Elsevier
The role of extracellular proteolysis in inflammatory demyelination, originally hypothesized
as a mechanism for myelin degradation, is increasingly recognized as a pathogenetic step
and as a target for therapy in human demyelinating disease. The activation of ubiquitous
plasminogen by urokinase (u-PA) and tissue-type plasminogen activator (t-PA), which is
associated with various neuropathologies, including multiple sclerosis (MS), is the key
initiator of the activation cascade of the four classes of matrix metalloproteinases (MMPs) …
as a mechanism for myelin degradation, is increasingly recognized as a pathogenetic step
and as a target for therapy in human demyelinating disease. The activation of ubiquitous
plasminogen by urokinase (u-PA) and tissue-type plasminogen activator (t-PA), which is
associated with various neuropathologies, including multiple sclerosis (MS), is the key
initiator of the activation cascade of the four classes of matrix metalloproteinases (MMPs) …