[HTML][HTML] Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose
C Shiota, O Larsson, KD Shelton, M Shiota… - Journal of Biological …, 2002 - ASBMB
The ATP-sensitive potassium channel is a key molecular complex for glucose-stimulated
insulin secretion in pancreatic β cells. In humans, mutations in either of the two subunits for
this channel, the sulfonylurea type 1 receptor (Sur1) or Kir6. 2, cause persistent
hyperinsulinemic hypoglycemia of infancy. We have generated and characterized Sur1 null
mice. Interestingly, these animals remain euglycemic for a large portion of their life despite
constant depolarization of membrane, elevated cytoplasmic free Ca 2+ concentrations, and …
insulin secretion in pancreatic β cells. In humans, mutations in either of the two subunits for
this channel, the sulfonylurea type 1 receptor (Sur1) or Kir6. 2, cause persistent
hyperinsulinemic hypoglycemia of infancy. We have generated and characterized Sur1 null
mice. Interestingly, these animals remain euglycemic for a large portion of their life despite
constant depolarization of membrane, elevated cytoplasmic free Ca 2+ concentrations, and …