[HTML][HTML] Processing of prothyrotropin-releasing hormone by the family of prohormone convertases
P Schaner, RB Todd, NG Seidah, EA Nillni - Journal of Biological Chemistry, 1997 - ASBMB
The post-translational processing of prothyrotropin-releasing hormone (pro-TRH 25–255)
has been extensively studied in our laboratory, and the processing pathway to mature TRH
has been elucidated. We have also demonstrated that recombinant PC1 and PC2 process
partially purified pro-TRH to cryptic peptides in vitro and that pro-TRH and PC1 mRNAs are
coexpressed in primary cultures of hypothalamic neurons. To further define the role of each
convertase, and particularly PC1 and PC2, in pro-TRH processing, recombinant vaccinia …
has been extensively studied in our laboratory, and the processing pathway to mature TRH
has been elucidated. We have also demonstrated that recombinant PC1 and PC2 process
partially purified pro-TRH to cryptic peptides in vitro and that pro-TRH and PC1 mRNAs are
coexpressed in primary cultures of hypothalamic neurons. To further define the role of each
convertase, and particularly PC1 and PC2, in pro-TRH processing, recombinant vaccinia …