[HTML][HTML] Functional analysis of interleukin 6 response elements (IL-6REs) on the human γ-fibrinogen promoter: binding of hepatic Stat3 correlates negatively with …
HO Duan, PJ Simpson-Haidaris - Journal of Biological Chemistry, 2003 - ASBMB
Several families of transcription factors play important roles in modulating liver-specific gene
expression during an acute phase response (APR). Stat3/APR factor is the main
transactivator of gene expression by the interleukin (IL)-6 family of cytokines signaling
through gp130. During an APR, fibrinogen (FBG) genes are coordinately up-regulated by IL-
6 and glucocorticoids. Except for rat γFBG, attempts to demonstrate direct binding of IL-6-
activated Stat3 to FBG CTGGGAA promoter elements have not been successful. Herein we …
expression during an acute phase response (APR). Stat3/APR factor is the main
transactivator of gene expression by the interleukin (IL)-6 family of cytokines signaling
through gp130. During an APR, fibrinogen (FBG) genes are coordinately up-regulated by IL-
6 and glucocorticoids. Except for rat γFBG, attempts to demonstrate direct binding of IL-6-
activated Stat3 to FBG CTGGGAA promoter elements have not been successful. Herein we …