[HTML][HTML] Biological processing of the cocaine and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3
A Dey, X Xhu, R Carroll, CW Turck, J Stein… - Journal of Biological …, 2003 - ASBMB
Cocaine and amphetamine-regulated transcript (CART), a neuroendocrine peptide
influencing reward, feeding/appetite, and stress responses is derived from two peptide
precursors of 129 and 116 amino acid (aa) residues that arise via alternative splicing from a
single Cart gene in rats and mice. The signal peptide constitutes the first 27 aa resulting in
pro-CART molecules of either 102 or 89 aa. In the present study, we have shown that pro-
CART is a substrate for the neuroendocrine subtilisin/kexin-like prohormone convertases …
influencing reward, feeding/appetite, and stress responses is derived from two peptide
precursors of 129 and 116 amino acid (aa) residues that arise via alternative splicing from a
single Cart gene in rats and mice. The signal peptide constitutes the first 27 aa resulting in
pro-CART molecules of either 102 or 89 aa. In the present study, we have shown that pro-
CART is a substrate for the neuroendocrine subtilisin/kexin-like prohormone convertases …
