[HTML][HTML] The roles of ATF3 in glucose homeostasis: a transgenic mouse model with liver dysfunction and defects in endocrine pancreas
AE Allen-Jennings, MG Hartman, GJ Kociba… - Journal of Biological …, 2001 - ASBMB
Activating transcription factor 3 (ATF3) is a member of the ATF/cAMP-response element-
binding protein family of transcription factors. It is a transcriptional repressor, and the
expression of its corresponding gene is induced by stress signals in a variety of tissues,
including the liver. In this report, we demonstrate that ATF3 is induced in the pancreas by
partial pancreatectomy, streptozotocin treatment, and ischemia coupled with reperfusion.
Furthermore, ATF3 is induced in cultured islet cells by oxidative stress. Interestingly …
binding protein family of transcription factors. It is a transcriptional repressor, and the
expression of its corresponding gene is induced by stress signals in a variety of tissues,
including the liver. In this report, we demonstrate that ATF3 is induced in the pancreas by
partial pancreatectomy, streptozotocin treatment, and ischemia coupled with reperfusion.
Furthermore, ATF3 is induced in cultured islet cells by oxidative stress. Interestingly …