Background Although human immunodeficiency virus (HIV)–related morbidity and mortality
rates in patients with advanced HIV infection who are treated with combination antiretroviral
drugs have declined, significant metabolic adverse effects associated with these regimens
have been increasingly recognized. However, since data from patients studied before and
after initiation of protease inhibitor (PI) therapy are scant, the true effect of PIs on these
metabolic changes remains unknown. Objectives To examine temporal trends in serum …