Background/Aims: We assessed mitochondrial morphology by electron microscopy and the
prevalence of a mitochondrial gene deletion in patients with nonalcoholic steatohepatitis
(NASH), alcohol-related liver disease and non-fatty liver diseases. Respiratory chain
function using a cytoplasmic hybrid (cybrid) assay was further studied in NASH patients and
healthy controls. Methods: Electron microscopy was performed in 26 specimens. Fifteen
patients were studied by polymerase chain reaction to detect a 520-bp deletion product of …