[HTML][HTML] Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA: a functional …
A IJpenberg, E Jeannin, W Wahli… - Journal of Biological …, 1997 - ASBMB
The malic enzyme (ME) gene is a target for both thyroid hormone receptors and peroxisome
proliferator-activated receptors (PPAR). Within the ME promoter, two direct repeat (DR)-1-
like elements, MEp and MEd, have been identified as putative PPAR response elements
(PPRE). We demonstrate that only MEp and not MEd is able to bind PPAR/retinoid X
receptor (RXR) heterodimers and mediate peroxisome proliferator signaling. Taking
advantage of the close sequence resemblance of MEp and MEd, we have identified crucial …
proliferator-activated receptors (PPAR). Within the ME promoter, two direct repeat (DR)-1-
like elements, MEp and MEd, have been identified as putative PPAR response elements
(PPRE). We demonstrate that only MEp and not MEd is able to bind PPAR/retinoid X
receptor (RXR) heterodimers and mediate peroxisome proliferator signaling. Taking
advantage of the close sequence resemblance of MEp and MEd, we have identified crucial …