Regulation of glyceroneogenesis and phosphoenolpyruvate carboxykinase by fatty acids, retinoic acids and thiazolidinediones: potential relevance to type 2 diabetes
J Tordjman, W Khazen, B Antoine, G Chauvet, J Quette… - Biochimie, 2003 - Elsevier
Recent studies brought adipocyte glyceroneogenesis back to the fore as an important
pathway in fatty acid homeostasis and underlined the key role played by cytosolic
phosphoenolpyruvate carboxykinase (PEPCK-C) in this pathway. The present review
analyses the mechanisms by which a series of hormones and nutrients affect PEPCK-C
gene transcription and glyceroneogenesis and describes evidence for disregulation of this
pathway in type 2 diabetes.
pathway in fatty acid homeostasis and underlined the key role played by cytosolic
phosphoenolpyruvate carboxykinase (PEPCK-C) in this pathway. The present review
analyses the mechanisms by which a series of hormones and nutrients affect PEPCK-C
gene transcription and glyceroneogenesis and describes evidence for disregulation of this
pathway in type 2 diabetes.