[HTML][HTML] Lethal hypoglycemic ketosis and glyceroluria in mice lacking both the mitochondrial and the cytosolic glycerol phosphate dehydrogenases

LJ Brown, RA Koza, L Marshall, LP Kozak… - Journal of Biological …, 2002 - ASBMB
The activities of either the mitochondrial or cytosolic glycerol phosphate dehydrogenase
(mGPD, cGPD) plus that of glycerol kinase are required for the use of glycerol in aerobic
metabolism and gluconeogenesis. A knockout mouse lacking mGPD has reduced body
weight and fertility but shows remarkably normal liver and muscle metabolite levels. The
BALB/cHeA mouse strain, which lacks cGPD, breeds well and is phenotypically normal,
although it demonstrates metabolite abnormalities in certain tissues. Crosses were made …