Inducible nitric oxide synthase inhibitors prolonged the survival of skin xenografts through selective down-regulation of pro-inflammatory cytokine and CC-chemokine …
JY Kim, D Kim, EM Lee, I Choi, CG Park, KS Kim… - Transplant …, 2003 - Elsevier
To elucidate the possible immunoregulatory role of nitric oxide (NO) in cellular xenograft
rejection we performed rat-to-mouse skin xenotransplantation. The rat skin engrafted mice
were treated with the inducible NO synthase (iNOS) inhibitors, aminoguanidine (AMG, 200
mg/kg) and NG-nitro-l-arginine methyl ester (l-NAME, 60 mg/kg) every other day until
rejection. Skin xenograft survival was monitored and immune cell infiltration and intragraft
cytokine and chemokine mRNA expressions were analyzed 7 days after grafting. Compared …
rejection we performed rat-to-mouse skin xenotransplantation. The rat skin engrafted mice
were treated with the inducible NO synthase (iNOS) inhibitors, aminoguanidine (AMG, 200
mg/kg) and NG-nitro-l-arginine methyl ester (l-NAME, 60 mg/kg) every other day until
rejection. Skin xenograft survival was monitored and immune cell infiltration and intragraft
cytokine and chemokine mRNA expressions were analyzed 7 days after grafting. Compared …
