The glucagonoma syndrome: a review of its features and discussion of new perspectives
MA Chastain - The American journal of the medical sciences, 2001 - Elsevier
Glucagonoma syndrome is a paraneoplastic phenomenon characterized by an islet alpha-
cell pancreatic tumor, necrolytic migratory erythema, diabetes mellitus, weight loss, anemia,
stomatitis, thromboembolism, and gastrointestinal and neuropsychiatric disturbances. These
clinical findings in association with hyperglucagonemia and demonstrable pancreatic tumor
establish the diagnosis. Glucagon itself is responsible for most of the observed signs and
symptoms, and its induction of hypoaminoacidemia is thought to lead to necrolytic migratory …
cell pancreatic tumor, necrolytic migratory erythema, diabetes mellitus, weight loss, anemia,
stomatitis, thromboembolism, and gastrointestinal and neuropsychiatric disturbances. These
clinical findings in association with hyperglucagonemia and demonstrable pancreatic tumor
establish the diagnosis. Glucagon itself is responsible for most of the observed signs and
symptoms, and its induction of hypoaminoacidemia is thought to lead to necrolytic migratory …