Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
E Lorenz, JP Mira, KL Frees… - Archives of internal …, 2002 - jamanetwork.com
Background Septic shock remains a significant health concern worldwide, and despite
progress in understanding the physiological and molecular basis of septic shock, the high
mortality rate of patients with septic shock remains unchanged. We recently identified a
common polymorphism in toll-like receptor 4 (TLR4) that is associated with
hyporesponsiveness to inhaled endotoxin or lipopolysaccharide in humans. Methods Since
TLR4 is a major receptor for lipopolysaccharide in mammals and gram-negative bacteria are …
progress in understanding the physiological and molecular basis of septic shock, the high
mortality rate of patients with septic shock remains unchanged. We recently identified a
common polymorphism in toll-like receptor 4 (TLR4) that is associated with
hyporesponsiveness to inhaled endotoxin or lipopolysaccharide in humans. Methods Since
TLR4 is a major receptor for lipopolysaccharide in mammals and gram-negative bacteria are …