Pre-B-cell colony-enhancing factor, a novel cytokine of human fetal membranes

S Ognjanovic, GD Bryant-Greenwood - American Journal of Obstetrics and …, 2002 - Elsevier
Objective: Our purpose was to determine whether pre-B-cell colony-enhancing factor (PBEF)
is expressed in the human fetal membranes during normal gestation and parturition in the
absence of infection and to show its effects on the expression of interleukin (IL)-6 and IL-8.
Study Design: PBEF was immunolocalized in the fetal membranes from early pregnancy, at
preterm, and at term. Its expression was quantitated by Northern analysis in separated
uninfected amnion, chorion, decidua, and placenta of patients at term before labor and in full …