[HTML][HTML] c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation
K Chen, JA Vita, BC Berk, JF Keaney - Journal of Biological Chemistry, 2001 - ASBMB
The phenotypic properties of the endothelium are subject to modulation by oxidative stress,
and the c-Jun N-terminal kinase (JNK) pathway is important in mediating cellular responses
to stress, although activation of this pathway in endothelial cells has not been fully
characterized. Therefore, we exposed endothelial cells to hydrogen peroxide (H 2 O 2) and
observed rapid activation of JNK within 15 min that involved phosphorylation of JNK and c-
Jun and induction of AP-1 DNA binding activity. Inhibition of protein kinase C and …
and the c-Jun N-terminal kinase (JNK) pathway is important in mediating cellular responses
to stress, although activation of this pathway in endothelial cells has not been fully
characterized. Therefore, we exposed endothelial cells to hydrogen peroxide (H 2 O 2) and
observed rapid activation of JNK within 15 min that involved phosphorylation of JNK and c-
Jun and induction of AP-1 DNA binding activity. Inhibition of protein kinase C and …