Over 12 years, from 1984 to 1995, we conducted a prospective study of overall and malaria
specific mortality among three rural populations in the Sahel, savanna and forest areas of
Senegal. The emergence of chloroquine resistance has been associated with a dramatic
increase in malaria mortality in each of the studied populations. After the emergence of
chloroquine resistance, the risk of malaria death among children 0–9 years old in the three
populations was multiplied by 2.1, 2.5 and 5.5, respectively. This is the first study to …