[HTML][HTML] Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis: GRP78/BiP and novel genes
K Kokame, H Kato, T Miyata - Journal of Biological Chemistry, 1996 - ASBMB
An elevated blood level of homocysteine is associated with arteriosclerosis and thrombosis.
The mechanisms by which homocysteine may promote vascular diseases have not been
elucidated yet. In the present study, we have applied a modified nonradioactive differential
display analysis to evaluate changes in gene expression induced by homocysteine
treatment of cultured human umbilical vein endothelial cells (HUVEC). We identified six up-
regulated and one down-regulated genes. One up-regulated gene was GRP78/BiP, a stress …
The mechanisms by which homocysteine may promote vascular diseases have not been
elucidated yet. In the present study, we have applied a modified nonradioactive differential
display analysis to evaluate changes in gene expression induced by homocysteine
treatment of cultured human umbilical vein endothelial cells (HUVEC). We identified six up-
regulated and one down-regulated genes. One up-regulated gene was GRP78/BiP, a stress …