Focal reductions of cerebral blood flow in amyotrophic lateral sclerosis: a [99mTc]-d, l-HMPAO SPECT study

G Waldemar, S Vorstrup, TS Jensen, A Johnsen… - Journal of the …, 1992 - Elsevier
We investigated regional cerebral blood flow (rCBF) using the [99 m Tc]-d, l-HMPAO
technique with brain dedicated high resolution single photon emission computer
tomography (SPECT) in 14 consecutive patients with amyotrophic lateral sclerosis (ALS),
median age 62 years (45–77). Global CBF, expressed in% relative to the cerebellum, was
significantly lower (P< 0.05) in the ALS group (80.5±6.7%) than in the control group of 14
age-matched healthy volunteers (87.0±7.5%). Eight patients (57%) had abnormal rCBF …