Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischemia
D Simovic, JM Isner, AH Ropper, A Pieczek… - Archives of …, 2001 - jamanetwork.com
Objective To investigate the effects of vascular endothelial growth factor gene therapy on
ischemic neuropathy in patients with critical limb ischemia. Design An open-label, dose-
escalating trial. Patients with angiographically proven critical leg ischemia received
injections of phVEGF 165 human plasmid in the muscles of the ischemic limb. Testing before
treatment and at 3 and 6 months included (1) symptom severity score,(2) clinical
examination score, and (3) electrophysiologic studies. Clinical and electrophysiologic …
ischemic neuropathy in patients with critical limb ischemia. Design An open-label, dose-
escalating trial. Patients with angiographically proven critical leg ischemia received
injections of phVEGF 165 human plasmid in the muscles of the ischemic limb. Testing before
treatment and at 3 and 6 months included (1) symptom severity score,(2) clinical
examination score, and (3) electrophysiologic studies. Clinical and electrophysiologic …