Only a few reports exist of cytogenetic studies in nasopharyngeal carcinoma (NPC),
probably because of the technical limitations of culturing solid tumors. We established a cell
line (cell-666) that was derived from an NPC xenograft growing in athymic nude mice.
Epstein-Barr virus (EBV) infection is one of the important etiologic factors of NPC. This cell
line has been shown to have the consistent presence of EBV by Epstein-Barr virus encoded
RNAs (EBER) in situ hybridization. Furthermore, aberrant methylation of 5′ CpG island of …