Passive Immunization with Melanin-Binding Monoclonal Antibodies Prolongs Survival of Mice with Lethal Cryptococcus neoformans Infection
AL Rosas, JD Nosanchuk, A Casadevall - Infection and immunity, 2001 - Am Soc Microbiol
AL Rosas, JD Nosanchuk, A Casadevall
Infection and immunity, 2001•Am Soc MicrobiolPassive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival
of and reduced the fungal burden in Cryptococcus neoformans-infected mice in comparison
to controls. MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans
cells, suggesting a new mechanism of antibody-mediated protection.
of and reduced the fungal burden in Cryptococcus neoformans-infected mice in comparison
to controls. MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans
cells, suggesting a new mechanism of antibody-mediated protection.
Abstract
Passive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden inCryptococcus neoformans-infected mice in comparison to controls. MAbs to melanin reduced the growth rate of in vitro-melanizedC. neoformans cells, suggesting a new mechanism of antibody-mediated protection.
American Society for Microbiology