Candidacidal activity prompted by N-terminus histatin-like domain of human salivary mucin (MUC7)
TL Gururaja, JH Levine, DT Tran… - … et Biophysica Acta (BBA …, 1999 - Elsevier
Histidine-rich peptides (histatins, Hsn) in saliva are thought to provide a non-immune
defense against Candida albicans. Sequence homology search of the human salivary
mucin, MUC7, against histatins revealed a domain at the N-terminus (R3–Q17) having 53%
identity to Hsn-5. To determine its candidacidal activity, this 15 residue basic histidine-rich
domain of MUC7 (I) was prepared by solid-phase Fmoc chemistry. Various N-and C-terminal
protected derivatives of I were also synthesized to correlate the effect of peptide overall …
defense against Candida albicans. Sequence homology search of the human salivary
mucin, MUC7, against histatins revealed a domain at the N-terminus (R3–Q17) having 53%
identity to Hsn-5. To determine its candidacidal activity, this 15 residue basic histidine-rich
domain of MUC7 (I) was prepared by solid-phase Fmoc chemistry. Various N-and C-terminal
protected derivatives of I were also synthesized to correlate the effect of peptide overall …