[HTML][HTML] Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity
JL Sepulveda, S Vlahopoulos, D Iyer, N Belaguli… - Journal of Biological …, 2002 - ASBMB
Herein, the restricted expression of serum response factors (SRF) closely overlapped
withNkx2-5 and GATA4 transcripts in early chick embryos coinciding with the earliest
appearance of cardiac α-actin (αCA) transcripts and nascent myocardial cells. The
combinatorial expression of SRF, a MADS box factor Nkx2-5 (a NK4 homeodomain), and/or
GATA4, a dual C4 zinc finger protein, in heterologous CV1 fibroblasts and Schneider 2
insect cells demonstrated synergistic induction of αCA promoter activity. These three factors …
withNkx2-5 and GATA4 transcripts in early chick embryos coinciding with the earliest
appearance of cardiac α-actin (αCA) transcripts and nascent myocardial cells. The
combinatorial expression of SRF, a MADS box factor Nkx2-5 (a NK4 homeodomain), and/or
GATA4, a dual C4 zinc finger protein, in heterologous CV1 fibroblasts and Schneider 2
insect cells demonstrated synergistic induction of αCA promoter activity. These three factors …
