cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32. 2→ q32. 3
K Yamamoto, H Kobayashi, A Arai, O Miura… - … and Genome Research, 1997 - karger.com
K Yamamoto, H Kobayashi, A Arai, O Miura, S Hirosawa, N Miyasaka
Cytogenetic and Genome Research, 1997•karger.comStudies of transcriptional activation by interferons and a variety of cytokines have led to the
identification of a family of proteins that serve as signal transducers and activators of
transcription (STAT). STAT4 is phosphorylated following interleukin (IL)-12 stimulation and is
essential for IL-12 signal transduction. The human STAT4 cDNA was cloned, and both
STAT4 and STAT1 genes were mapped to human chromosome bands 2q32. 2→ q32. 3 by
fluorescence in situ hybridization. These results suggest that STAT4 and STAT1 may have …
identification of a family of proteins that serve as signal transducers and activators of
transcription (STAT). STAT4 is phosphorylated following interleukin (IL)-12 stimulation and is
essential for IL-12 signal transduction. The human STAT4 cDNA was cloned, and both
STAT4 and STAT1 genes were mapped to human chromosome bands 2q32. 2→ q32. 3 by
fluorescence in situ hybridization. These results suggest that STAT4 and STAT1 may have …
Abstract
Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription (STAT). STAT4 is phosphorylated following interleukin (IL)-12 stimulation and is essential for IL-12 signal transduction. The human STAT4 cDNA was cloned, and both STAT4 and STAT1 genes were mapped to human chromosome bands 2q32.2→q32.3 by fluorescence in situ hybridization. These results suggest that STAT4 and STAT1 may have arisen via a tandem gene duplication. However, human STAT1 is expressed ubiquitously, whereas human STAT4 is expressed in several tissues including spleen, heart, brain, peripheral blood cells, and testis.
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