Inducible gene expression and gene modification in transgenic mice
FRE JAISSER - Journal of the American Society of Nephrology, 2000 - journals.lww.com
Animal transgenesis has proven to be useful for physiologic as well as pathophysiologic
studies. Animal models with conditional expression of a transgene of interest or with a
conditional gene mutation can be generated. This permits spatial and temporal control of the
expression of the transgene or of gene mutations previously introduced by gene targeting.
These approaches allow the generation of models suitable for physiologic analysis or
models mimicking disease states.
studies. Animal models with conditional expression of a transgene of interest or with a
conditional gene mutation can be generated. This permits spatial and temporal control of the
expression of the transgene or of gene mutations previously introduced by gene targeting.
These approaches allow the generation of models suitable for physiologic analysis or
models mimicking disease states.