Regulation of inducible nitric oxide synthase gene expression in vascular smooth muscle cells
M Hecker, M Cattaruzza, AH Wagner - General Pharmacology: The …, 1999 - Elsevier
Formation of nitric oxide (NO) by the constitutive calcium-dependent NO synthase expressed
in endothelial cells plays an important role in the control of local blood flow and vascular
homeostasis. Expression of the inducible calcium-independent NO synthase (iNOS) in
vascular smooth muscle cells (VSMC), on the other hand, is thought to play a potentially
detrimental role in the pathogenesis of chronic inflammation or septic shock. In vascular
injury, however, iNOS expression in VSMC may be beneficial as a compensatory …
in endothelial cells plays an important role in the control of local blood flow and vascular
homeostasis. Expression of the inducible calcium-independent NO synthase (iNOS) in
vascular smooth muscle cells (VSMC), on the other hand, is thought to play a potentially
detrimental role in the pathogenesis of chronic inflammation or septic shock. In vascular
injury, however, iNOS expression in VSMC may be beneficial as a compensatory …