[HTML][HTML] Interaction between ICOS-B7RP1 and B7-CD28 costimulatory pathways in alloimmune responses in vivo
AD Salama, X Yuan, A Nayer, A Chandraker… - American Journal of …, 2003 - Elsevier
The B7-CD28 pathway is one of the foremost costimulatory pathways involved in T-cell
activation. Recently, a number of additional costimulatory pathways have been described
and preliminary data suggest that they play important roles in alloimmunity. However, the
interactions between these different pathways are not well understood. We studied the effect
of targeting ICOS ligand, B7RP1, in a rat cardiac transplant model, with and without
concomitant blockade of the B7 pathway using CTLA4Ig. In a fully mismatched WF to LEW …
activation. Recently, a number of additional costimulatory pathways have been described
and preliminary data suggest that they play important roles in alloimmunity. However, the
interactions between these different pathways are not well understood. We studied the effect
of targeting ICOS ligand, B7RP1, in a rat cardiac transplant model, with and without
concomitant blockade of the B7 pathway using CTLA4Ig. In a fully mismatched WF to LEW …