[HTML][HTML] Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein
Z Li, X Na, D Wang, SR Schoen, EM Messing… - Journal of Biological …, 2002 - ASBMB
von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome caused by germline
mutations of theVHL gene. Recent studies suggest that VHL protein (pVHL) is a component
of an E3 ubiquitin ligase, but the detailed biological function of pVHL remains to be
determined. To further elucidate the biological functions of pVHL, we searched pVHL-
interacting proteins using yeast two-hybrid screening. A novel protein named VHL-
interacting deubiquitinating enzyme 1 (VDU1) was identified as being able to directly …
mutations of theVHL gene. Recent studies suggest that VHL protein (pVHL) is a component
of an E3 ubiquitin ligase, but the detailed biological function of pVHL remains to be
determined. To further elucidate the biological functions of pVHL, we searched pVHL-
interacting proteins using yeast two-hybrid screening. A novel protein named VHL-
interacting deubiquitinating enzyme 1 (VDU1) was identified as being able to directly …