Role of cytokines in rheumatoid arthritis
M Feldmann, FM Brennan… - Annual review of …, 1996 - annualreviews.org
▪ Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such
as IL-8 are abundant in all patients regardless of therapy. This is compensated to some
degree by the increased production of anti-inflammatory cytokines such as IL-10 and TGFβ
and cytokine inhibitors such as IL-1ra and soluble TNF-R. However, this upregulation in
homeostatic regulatory mechanisms is not sufficient as these are unable to neutralize all the …
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such
as IL-8 are abundant in all patients regardless of therapy. This is compensated to some
degree by the increased production of anti-inflammatory cytokines such as IL-10 and TGFβ
and cytokine inhibitors such as IL-1ra and soluble TNF-R. However, this upregulation in
homeostatic regulatory mechanisms is not sufficient as these are unable to neutralize all the …