[HTML][HTML] Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice
Excess tissue glucocorticoid action may underlie the dyslipidemia, insulin resistance, and
impaired glucose tolerance of the metabolic syndrome. 11β-Hydroxysteroid dehydrogenase
type 1 (11β-HSD-1) catalyzes conversion of circulating inert 11-dehydrocorticosterone into
active corticosterone, thus amplifying local intracellular glucocorticoid action, particularly in
liver. The importance of 11β-HSD-1 in glucose homeostasis is suggested by the resistance
of 11β-HSD-1−/− mice to hyperglycemia upon stress or obesity, due to attenuated …
impaired glucose tolerance of the metabolic syndrome. 11β-Hydroxysteroid dehydrogenase
type 1 (11β-HSD-1) catalyzes conversion of circulating inert 11-dehydrocorticosterone into
active corticosterone, thus amplifying local intracellular glucocorticoid action, particularly in
liver. The importance of 11β-HSD-1 in glucose homeostasis is suggested by the resistance
of 11β-HSD-1−/− mice to hyperglycemia upon stress or obesity, due to attenuated …