Skeletal muscle glucocorticoid receptor density and insulin resistance

RM Reynolds, KE Chapman, JR Seckl, BR Walker… - Jama, 2002 - jamanetwork.com
Methods We obtained biopsies of vastus lateralis skeletal muscle under local anesthesia
from 23 men without fasting hyperglycemia participating in the the Uppsala Longitudinal
Study of Adult Men. 3 As previously described, participants underwent a 75-g oral glucose
tolerance test, euglycemic hyperinsulinemic clamp, and ambulatory blood pressure
recording. Height, weight, and waist and hip circumferences were measured. Glucocorticoid
receptor messenger RNA (mRNA) levels were measured in muscle total RNA using a …