The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation
Y Aoka, FL Johnson, K Penta, K Hirata, C Hidai… - Microvascular …, 2002 - Elsevier
Del1 is a unique αvβ3 integrin ligand that is produced by endothelial cells, and thus
provides an autocrine signaling pathway in this cell type. It is expressed transiently in the
embryo and mediates cell attachment, migration, and activation of cytoplasmic signaling
molecules in focal contacts. Del1 also activates angiogenesis in the chick chorioallantoic
membrane assay. Reexpression of this embryonic signaling molecule has now been
documented in naturally occurring human tumors, where it is expressed by both tumor cells …
provides an autocrine signaling pathway in this cell type. It is expressed transiently in the
embryo and mediates cell attachment, migration, and activation of cytoplasmic signaling
molecules in focal contacts. Del1 also activates angiogenesis in the chick chorioallantoic
membrane assay. Reexpression of this embryonic signaling molecule has now been
documented in naturally occurring human tumors, where it is expressed by both tumor cells …