IL-13 induces eosinophil recruitment into the lung by an IL-5–and eotaxin-dependent mechanism
Background: IL-13 induces several characteristic features of asthma, including airway
eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the
mechanisms involved are largely unknown. Objective: We hypothesized that IL-13–induced
inflammatory changes in the lung were dependent in part on IL-5 and eotaxin, two
eosinophil-selective cytokines. Methods: Recombinant murine IL-13 was repeatedly
administered to the lung by intranasal delivery until the characteristic features of asthma …
eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the
mechanisms involved are largely unknown. Objective: We hypothesized that IL-13–induced
inflammatory changes in the lung were dependent in part on IL-5 and eotaxin, two
eosinophil-selective cytokines. Methods: Recombinant murine IL-13 was repeatedly
administered to the lung by intranasal delivery until the characteristic features of asthma …