[HTML][HTML] Interleukin-5-mediated allergic airway inflammation inhibits the human surfactant protein C promoter in transgenic mice
A Mishra, TE Weaver, DC Beck… - Journal of Biological …, 2001 - ASBMB
Allergen challenge in the lung of humans and animals is associated with surfactant
dysfunction, but the mechanism of this effect has not been established. By using a murine
model of asthma we now report the effect of allergen-induced airway inflammation on the
expression of transgenes regulated by the human surfactant protein (hSP)-C promoter. The
hSP-C 3.7-kilobase pair promoter was used to direct the expression of eotaxin, an
eosinophil-selective chemokine, into the lungs of several transgenic lines. As expected, the …
dysfunction, but the mechanism of this effect has not been established. By using a murine
model of asthma we now report the effect of allergen-induced airway inflammation on the
expression of transgenes regulated by the human surfactant protein (hSP)-C promoter. The
hSP-C 3.7-kilobase pair promoter was used to direct the expression of eotaxin, an
eosinophil-selective chemokine, into the lungs of several transgenic lines. As expected, the …