[HTML][HTML] Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors α and β

JJ Repa, KE Berge, C Pomajzl, JA Richardson… - Journal of Biological …, 2002 - ASBMB
Mutations in the ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 have recently
been shown to cause the autosomal recessive disorder sitosterolemia. Here we
demonstrate that the ABCG5 and ABCG8 genes are direct targets of the oxysterol receptors
liver X receptor (LXR) α and LXRβ. Diets containing high cholesterol markedly increased the
expression of ABCG5/G8 mRNA in mouse liver and intestine. This increase was also
observed using synthetic ligands of LXR and its heterodimeric partner, the retinoid X …