[HTML][HTML] ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2

G He, S Gupta, M Yi, P Michaely, HH Hobbs… - Journal of Biological …, 2002 - ASBMB
Mutations in the phosphotyrosine binding domain protein ARH cause autosomal recessive
hypercholesterolemia, a disorder caused by defective internalization of low density
lipoprotein receptors (LDLR) in the liver. To examine the function of ARH, we used pull-
down experiments to test for interactions between ARH, the LDLR, and proteins involved in
clathrin-mediated endocytosis. The phosphotyrosine binding domain of ARH interacted with
the internalization sequence (NPVY) in the cytoplasmic tail of LDLR in a sequence-specific …