Diversity in protein recognition by PTB domains

JD Forman-Kay, T Pawson - Current opinion in structural biology, 1999 - Elsevier
JD Forman-Kay, T Pawson
Current opinion in structural biology, 1999Elsevier
Phosphotyrosine-binding (PTB) domains were originally identified as modular domains that
recognize phosphorylated Asn-Pro-Xxx-pTyr-containing proteins. Recent binding and
structural studies of PTB domain complexes with target peptides have revealed a number of
deviations from the previously described mode of interaction, with respect to both the
sequences of possible targets and their structures within the complexes. This diversity of
recognition by PTB domains extends and strengthens our general understanding of modular …
Phosphotyrosine-binding (PTB) domains were originally identified as modular domains that recognize phosphorylated Asn-Pro-Xxx-pTyr-containing proteins. Recent binding and structural studies of PTB domain complexes with target peptides have revealed a number of deviations from the previously described mode of interaction, with respect to both the sequences of possible targets and their structures within the complexes. This diversity of recognition by PTB domains extends and strengthens our general understanding of modular binding domain recognition.
Elsevier