Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1. 3 potassium channels
GC Koo, JT Blake, K Shah, MJ Staruch, F Dumont… - Cellular …, 1999 - Elsevier
The voltage-gated potassium channel, Kv1. 3, is specifically expressed on human
lymphocytes, where it controls membrane potential and calcium influx. Blockade of Kv1. 3
channels by margatoxin was previously shown to prevent T cell activation and attenuate
immune responses in vivo. In the present study, a triterpene natural product, correolide, was
found to block Kv1. 3 channels in human and miniswine T cells by electrophysiological
characterization. T cell activation events, such as anti-CD3-induced calcium elevation, IL-2 …
lymphocytes, where it controls membrane potential and calcium influx. Blockade of Kv1. 3
channels by margatoxin was previously shown to prevent T cell activation and attenuate
immune responses in vivo. In the present study, a triterpene natural product, correolide, was
found to block Kv1. 3 channels in human and miniswine T cells by electrophysiological
characterization. T cell activation events, such as anti-CD3-induced calcium elevation, IL-2 …