Objective: To review recent advances in understanding the role of leptin in the physiology
and pathophysiology of reproduction, with a focus on relevant clinical situations. Design: A
MEDLINE computer search was performed to identify relevant articles. Result (s): Leptin, an
adipocyte hormone important in regulating energy homeostasis, interacts with the
reproductive axis at multiple sites, with stimulatory effects at the hypothalamus and pituitary
and inhibitory actions at the gonads. More recently, leptin has been shown to play a role in …