Subtle acquired renal injury as a mechanism of salt-sensitive hypertension
RJ Johnson, J Herrera-Acosta… - … England Journal of …, 2002 - Mass Medical Soc
RJ Johnson, J Herrera-Acosta, GF Schreiner, B Rodríguez-Iturbe
New England Journal of Medicine, 2002•Mass Medical SocSalt sensitivity is present in about half of people with essential hypertension; decreasing salt
intake ameliorates the hypertension. This review provides an explanation of how initially
subtle renal injury promotes a tendency toward hypertension. The kidneys, initially normal in
many persons with early primary hypertension, sustain subclinical injury over time, resulting
in arteriolosclerosis and tubulointerstitial disease that lead to established hypertension.
intake ameliorates the hypertension. This review provides an explanation of how initially
subtle renal injury promotes a tendency toward hypertension. The kidneys, initially normal in
many persons with early primary hypertension, sustain subclinical injury over time, resulting
in arteriolosclerosis and tubulointerstitial disease that lead to established hypertension.
Salt sensitivity is present in about half of people with essential hypertension; decreasing salt intake ameliorates the hypertension. This review provides an explanation of how initially subtle renal injury promotes a tendency toward hypertension. The kidneys, initially normal in many persons with early primary hypertension, sustain subclinical injury over time, resulting in arteriolosclerosis and tubulointerstitial disease that lead to established hypertension.
The New England Journal Of Medicine