[PDF][PDF] Progressive renal failure—inability of podocytes to replicate and the consequences for development of glomerulosclerosis

W Kriz - Nephrology Dialysis Transplantation, 1996 - researchgate.net
W Kriz
Nephrology Dialysis Transplantation, 1996researchgate.net
The irreversible decrease of renal function in chronic renal failure results from progressing
nephron loss. When studied by histopathology, the nephron loss follows a pattern of
degeneration designated focal segmental glomerulosclerosis. We investigated this
degenerative process in several animal models [1—4]. In agreement with others [5] we have
come to the conclusion that the progressive nature of this disease is ultimately based on the
inability of podocytes to replicate.
The irreversible decrease of renal function in chronic renal failure results from progressing nephron loss. When studied by histopathology, the nephron loss follows a pattern of degeneration designated focal segmental glomerulosclerosis. We investigated this degenerative process in several animal models [1—4]. In agreement with others [5] we have come to the conclusion that the progressive nature of this disease is ultimately based on the inability of podocytes to replicate.
researchgate.net