Activation of oncogenic pathways in degenerating neurons in Alzheimer disease
X Zhu, AK Raina, H Boux, ZL Simmons… - International Journal of …, 2000 - Elsevier
A number of recent findings have highlighted the similarities between neurogenesis during
development and neurodegeneration during Alzheimer disease. In fact, neuronal
populations that are known to degenerate in Alzheimer disease exhibit phenotypic changes
characteristic of cells re-entering the cell division cycle. In this study, we extended these
findings by investigating components of the cell cycle, known to trigger progression through
G1 through activation of signal transduction cascades. Specifically, we found that proteins …
development and neurodegeneration during Alzheimer disease. In fact, neuronal
populations that are known to degenerate in Alzheimer disease exhibit phenotypic changes
characteristic of cells re-entering the cell division cycle. In this study, we extended these
findings by investigating components of the cell cycle, known to trigger progression through
G1 through activation of signal transduction cascades. Specifically, we found that proteins …
