[HTML][HTML] Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation
Activation of the epidermal growth factor (EGF) receptor by its ligand, EGF, rapidly enhances
receptor internalization and degradation, which desensitizes receptor signaling. In contrast,
we have shown previously that exposure to oxidative stress in the form of hydrogen peroxide
(H 2 O 2) activated the EGF receptor but that the levels of activated receptors did not decline,
which resulted in prolonged receptor signaling. This study provides mechanistic insights into
these different modes of EGF receptor activation. Here we demonstrate that the pattern of …
receptor internalization and degradation, which desensitizes receptor signaling. In contrast,
we have shown previously that exposure to oxidative stress in the form of hydrogen peroxide
(H 2 O 2) activated the EGF receptor but that the levels of activated receptors did not decline,
which resulted in prolonged receptor signaling. This study provides mechanistic insights into
these different modes of EGF receptor activation. Here we demonstrate that the pattern of …