[HTML][HTML] Dueling activities of AIF in cell death versus survival: DNA binding and redox activity
SA Lipton, E Bossy-Wetzel - Cell, 2002 - cell.com
Cell, 2002•cell.com
Apoptosis-inducing factor (AIF) was originally discovered as a mitochondrial protein that, like
cytochrome c, is released into the cytoplasm during cell death. New evidence suggests,
however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA
binding region is proapoptotic.
cytochrome c, is released into the cytoplasm during cell death. New evidence suggests,
however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA
binding region is proapoptotic.
Abstract
Apoptosis-inducing factor (AIF) was originally discovered as a mitochondrial protein that, like cytochrome c, is released into the cytoplasm during cell death. New evidence suggests, however, that a redox-active enzymatic region of AIF may be antiapoptotic while a DNA binding region is proapoptotic.
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