[HTML][HTML] Neurodegeneration: a non-apoptotic role for AIF in the brain
A Bonni - Current biology, 2003 - cell.com
Current biology, 2003•cell.com
A recent report provides new insights into the mechanisms of neurodegeneration. In a
mouse mutant with progressive cerebellar and retinal degeneration, the expression of the
apoptotic protein AIF was found to be downregulated leading paradoxically to apoptosis of
neurons that is associated with an imbalance in free radical metabolism and cell cycle re-
entry.
mouse mutant with progressive cerebellar and retinal degeneration, the expression of the
apoptotic protein AIF was found to be downregulated leading paradoxically to apoptosis of
neurons that is associated with an imbalance in free radical metabolism and cell cycle re-
entry.
Abstract
A recent report provides new insights into the mechanisms of neurodegeneration. In a mouse mutant with progressive cerebellar and retinal degeneration, the expression of the apoptotic protein AIF was found to be downregulated leading paradoxically to apoptosis of neurons that is associated with an imbalance in free radical metabolism and cell cycle re-entry.
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