Kainic acid-induced apoptosis in cerebellar granule neurons: an attempt at cell cycle re-entry
E Verdaguer, E García-Jordà, AM Canudas… - …, 2002 - journals.lww.com
This study was undertaken to investigate whether kainic acid (KA) may regulate the
expression of several proteins which plays an important role in cell-cycle progression in
cerebellar granule neurons (CGNs). KA induced decrease in MTT values in a concentration
dependent way. Flow cytometric analysis showed that KA was able to induce 30% apoptosis
in CGNs. Apoptotic nuclear condensation were detected 24 h of exposure to KA (200 μM).
An associated marked increase in DNA synthesis, measured by BrdU incorporation, was …
expression of several proteins which plays an important role in cell-cycle progression in
cerebellar granule neurons (CGNs). KA induced decrease in MTT values in a concentration
dependent way. Flow cytometric analysis showed that KA was able to induce 30% apoptosis
in CGNs. Apoptotic nuclear condensation were detected 24 h of exposure to KA (200 μM).
An associated marked increase in DNA synthesis, measured by BrdU incorporation, was …
