An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell …
DS Cassarino, JP Bennett Jr - Brain Research Reviews, 1999 - Elsevier
There is mounting evidence for mitochondrial involvement in neurodegenerative diseases
including Alzheimer's and Parkinson's disease and amyotrophic lateral sclerosis.
Mitochondrial DNA mutations, whether inherited or acquired, lead to impaired electron
transport chain (ETC) functioning. Impaired electron transport, in turn, leads to decreased
ATP production, formation of damaging free-radicals, and altered calcium handling. These
toxic consequences of ETC dysfunction lead to further mitochondrial damage including …
including Alzheimer's and Parkinson's disease and amyotrophic lateral sclerosis.
Mitochondrial DNA mutations, whether inherited or acquired, lead to impaired electron
transport chain (ETC) functioning. Impaired electron transport, in turn, leads to decreased
ATP production, formation of damaging free-radicals, and altered calcium handling. These
toxic consequences of ETC dysfunction lead to further mitochondrial damage including …