[HTML][HTML] The inactivation mechanism of low molecular weight phosphotyrosine-protein phosphatase by H2O2
A Caselli, R Marzocchini, G Camici, G Manao… - Journal of Biological …, 1998 - ASBMB
Low molecular weight phosphotyrosine-protein phosphatase (LMW-PTP) shares no general
sequence homology with other PTPs, although it has an active site sequence motif
CXXXXXR and a reaction mechanism identical to those of all PTPs. The main function of this
enzyme is the down-regulation of platelet-derived growth factor and insulin receptors. Both
human LMW-PTP isoenzymes are inactivated by H 2 O 2. The enzymes are protected from
inactivation by P i, a competitive inhibitor, suggesting that the H 2 O 2 reaction is directed to …
sequence homology with other PTPs, although it has an active site sequence motif
CXXXXXR and a reaction mechanism identical to those of all PTPs. The main function of this
enzyme is the down-regulation of platelet-derived growth factor and insulin receptors. Both
human LMW-PTP isoenzymes are inactivated by H 2 O 2. The enzymes are protected from
inactivation by P i, a competitive inhibitor, suggesting that the H 2 O 2 reaction is directed to …