[HTML][HTML] Monitoring Reactions of Nitric Oxide with Peptides and Proteins by Electrospray Ionization-Mass Spectrometry (∗)
UA Mirza, BT Chait, HM Lander - Journal of Biological Chemistry, 1995 - ASBMB
Recent studies have demonstrated the biological importance of the interaction of nitric oxide
(NO) with proteins. Protein-associated targets of NO include heme, Cys, and Tyr.
Electrospray ionization-mass spectrometry was used to monitor the results of exposure of
model peptides and an enzyme to NO under different conditions and thus addressed
aspects of NO-protein interactions. The molecular mass of a decapeptide containing a single
Cys residue increased by 29 Da upon treatment with NO under aerobic and acidic …
(NO) with proteins. Protein-associated targets of NO include heme, Cys, and Tyr.
Electrospray ionization-mass spectrometry was used to monitor the results of exposure of
model peptides and an enzyme to NO under different conditions and thus addressed
aspects of NO-protein interactions. The molecular mass of a decapeptide containing a single
Cys residue increased by 29 Da upon treatment with NO under aerobic and acidic …